What is the onset typically seen with CLARE?

What is the onset typically seen with CLARE?

• A. Chronic progression over weeks
• B. Gradual onset over months
• C. Acute, happens overnight
• D. Sudden improvement with time

Answer: (C)

CLARE shows an abrupt, acute onset that happens quickly after overnight wear of soft contact lenses. This condition typically develops within hours, as tear-film contamination and lens-induced hypoxia trigger a rapid inflammatory response in the cornea and conjunctiva. Because of its sudden timing, it contrasts with slower, weeks-to-months progression seen in other conditions, and it isn’t something that simply improves with time. The hallmark is this overnight, rapid onset, making that description the best fit.

CLARE shows an abrupt, acute onset that happens quickly after overnight wear of soft contact lenses. This condition typically develops within hours, as tear-film contamination and lens-induced hypoxia trigger a rapid inflammatory response in the cornea and conjunctiva. Because of its sudden timing, it contrasts with slower, weeks-to-months progression seen in other conditions, and it isn’t something that simply improves with time. The hallmark is this overnight, rapid onset, making that description the best fit.